Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people
- VernacularTitle:汉族人群酒精性肝病ALDH2和CYP2E1基因多态性研究
- Author:
Aimin LENG
;
El ET
- Publication Type:Journal Article
- Keywords:
Alcoholic liver disease;
Aldehyde dehydrogenase;
Cytochrome P4502E1;
Gene polymorphism
- From:Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between genetic polymorphism of ALDH2 and CYP2E1 and alcoholic liver disease(ALD) in Han people. Methods:PCR-RFLP was used to detect the frequencies of gene types and allele of ALDH and CYP2E1 in health control group(45 cases),ALD group(48 cases),alcohol dependent group(38 cases) and non-ALD(NALD) group(42 cases),and the frequencies were compared. Results:The difference of the frequencies of ALDH2*1 and ALDH2*2 had statistic significance between health control group and ALD group,and between in ALD group and NALD group(P
