Study on the Relative Bioavailability of Micro-emulsified Genistein in Rabbits
- VernacularTitle:染料木素自微乳在家兔体内的相对生物利用度研究
- Author:
Xianhua DU
;
Xin NIU
;
Qianjin FENG
;
Rongting XU
;
Hong DU
;
Haiyan LI
- Publication Type:Journal Article
- Keywords:
Micro-emulsified genistein;
HPLC;
Pharmacokinetics;
Relative bioava ilability
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics and the relative bioavailabi lity of micro-emulsified genistein in rabbits. Methods Rabbits received gastric gavage of micro-emulsified genistein and CMC-Na suspension of genistein. Then the genistein content in rabbit plasma at different time was determined by HPLC ,concentration-time curve was drafted,and the pharmacokinetic parameters and the relative bioavailability were calculated. Results The main parameters of mic ro-emulsified genistein and CMC-Na suspension of genistein were as follows:AU C0→10h being(24.90?1.24)and(10.71?0.86)?g?h?mL-1,Cmax being(4.02?0.20)a nd(0.99?0.04)?g?mL-1,Tmax being 2 h and 4 h,respectively. The relative bio availability of micro-emulsified genistein was 232.49 %. Conclusion Micro-emu lsified genistein system can improve the bioavailability of genistein evidently.
