Experimental Study of Anti-aging Effect of Yangyan Quban Particles on Aging Model Mice’s Skin Caused by D-galactose
- VernacularTitle:养颜祛斑颗粒抗D-半乳糖所致小鼠皮肤衰老作用
- Author:
Qian WANG
;
Huiqin GAO
- Publication Type:Journal Article
- Keywords:
Yangyan Quban particles;
skin aging;
D-galactose;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of anti-aging effect of Yangyan Quban particles on the aging skin. Methods With the dose of D-galactose 1000 mg/(kg?d) by sc administration to the female mice for 42 days, the aging model was established. The mice received Yangyan Quban particles (6.68, 3.34, 1.67 g/kg) by ig administration at the same time of injecting D-galactose. Forty-two days later, the dorsal skin samples were collected to determine glutathione peroxidase (GSH-Px) activity and serum estradiol (E2) contents, and the influence on uterus, ovary, skin dry and wet weight and the amount of water intake were studied. Results Compared with the aged model mice, the GSH-Px activity and E2 contents in the mice treated with Yangyan Quban particles were increased remarkably, especially the medium is the best dose (P
