Protective Effects of Total Flavones of Herba Epimedii on Focal Cerebral Ischemia in Rats
- VernacularTitle:淫羊藿总黄酮对大鼠局灶性脑缺血的保护作用
- Author:
Lei SHEN
;
Ge ZHANG
;
Yulin WU
- Publication Type:Journal Article
- Keywords:
Total Flavones of Herba Epimedii;
Focal Cerebral Ischemia;
Protective effect Rats
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of total flavones of Herba Epimedii(TFE)on focal cerebral ischemia of rats.Methods Rat model of middle cerebral artery occlusion was established.With Jinnaduo as a positive control drug,the effect of TFE on the neurological behavior of cerebral ischemia rat,the cerebral water volume,the cerebral infarction area,the cerebral biochemistry and the pathologic change of brain were evaluated.Results TFE improved rats neurological behavior,decreased the cerebral water volume,reduced cerebral infarction area,increased ATPase and SOD activity,decreased MDA content,and also improved the pathological changes of ischemic brain.Conclusion TFE have the protective effect on cerebral ischemia in rats,its mechanism may be concerned about improving energy metabolism and anti-oxidation.
