Inhibition of ginkgo flavones against aggregation and fibrogenesis of A?_(1-42)
- VernacularTitle:银杏黄酮抑制A?_(1-42)聚集和纤维形成的分子机制
- Author:
Guangwu LI
;
Zhenhua REN
;
Peiyuan WANG
;
Min TANG
;
Huaqiao WANG
- Publication Type:Journal Article
- Keywords:
A?_(1-42) aggregation;
Alzheimer's disease;
?-sheet;
ginkgo flavones
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To gain the molecular mechanism of active ingredients of EGb 761(ginkgo flavones and ginkgo lides) for the inhibition against A?_(1-42) aggregation and fibrogenesis.METHODS:Circular dichroism spectra(CD) and FI-IR were used to curve-fit and analyze the change in A?_(1-42) second structure under A? aged condition and intervention of ginkgo flavones and ginkgo lides.RESULTS:Analysis that was made of 1700-1600 m(-1) amide-Ⅰ-band and curve fitting indicated that after 30 min to 72-incubation,increase of ?-sheet in A?_(1-42) by(18.5%),but the reduction of ?-sheet by(50.95%) and(36.09%) in 72 h incubation with ginko flavones and ginkgo lides,respectively.And increase of ?-turn by(56.56%) and(46.56%) in sane condition.CONCLUSION:Obviously,?-sheet turned into ?-turn.-CH_2 and-CH groups of ketones and alkanes engaged in A?_(1-42) molecular change.
