The relationship between polymorphism in XRCC1 and TNM staging and lymph node metastasis of esophageal squamous cell carcinoma
- VernacularTitle:DNA修复基因XRCC1多态与食管癌TNM分期及区域淋巴结转移的相关性研究
- Author:
Jianwei LIU
;
Wei LEI
;
Jianxin MA
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms Neoplasm staging Neoplasm metastasis Lymph nodes DNA repair Genotype
- From:Chinese Journal of Thoracic and Cardiovascular Surgery
1995;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the relationship between polymorphism of XRCC1 Arg194Trp Arg399Gln and ESCC TNM stage and regional lymph node metastasis. Methods PCR and PCR-RFLP were used to detect polymorphism of XRCC1 Arg194Trp and Arg399Gin. The results were analyzed and compared to TNM staging and regional lymph node metastasis. Results The XRCC1 194Arg/Trp and 399Arg/Arg wildtype in ESCC with metastasis is 32.3%, which is higher than 194Arg/Arg (20.0%, P=0.01). There was no remarkable difference between IIb-IV stage ESCC with lymph node metastasis and 0-IIa stage without metastasis. Conclusion The ESCC patients with 194 variability and 399 wildtype had high metastasis rate, XRCC1 Arg194Trp and Arg399Gln had relationship with ESCC TNM stage and lymph node metastasis. Both of them affected to prognosis of ESCC.
