Prophylactic Effects of Choline Chloride on Muscle Atrophy in Tail-suspended Rats
- VernacularTitle:氯化胆碱对尾吊大鼠比目鱼肌肌萎缩对抗效果的观察
- Author:
Yunfang GAO
;
Zhixian HE
;
Xiaoli FAN
;
Sudi WU
;
Xinai SONG
- Publication Type:Journal Article
- Keywords:
weightlessness simulation;
choline chloride;
myosin ATPase;
muscle atrophy
- From:Space Medicine & Medical Engineering
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of choline chloride on activities of myosin adenosine triphosphatase (mATPase) of muscle fibres and muscle atrophy in tail-suspended rats. Method Twenty-four adult female Sprague-dawley rats were averagely divided into 3 groups matched for body mass:control group(CON),tail suspension group(TS) and tail suspension group associated with choline chloride(TS+Cch).Weightlessness was simulated by 14 d tail suspension of rats;gastric lavage with choline chloride was given to 1/2 of the rats during tail suspension (15 mg/kg body weight.i.g.).Activities of myosin adenosine triphosphatase (mATpase) of intrafusal and extrafusal fibres in soleus (SOL) muscle were determined by Ca 2+-ATPase method.Paraffin sections of the soleus muscle were prepared by routine histochemistry method. Result After tail suspension for 14 d it was found: 1) percentage of type Ⅱ fibre in SOL of rats treated with choline chloride decreased distinctly as compared with that in the untreated rats (P
