A Study on the Sedative and Hypnotic Effects of Ganoderma lucidum Brewage
- VernacularTitle:灵芝生料酿制液镇静催眠作用的研究
- Author:
Guiying HUANG
;
Jiuyao ZHOU
;
Huifang LIAO
;
Xuezhen LIAO
- Publication Type:Journal Article
- Keywords:
Ganoderma lucidum Brewage;
Sedation;
Hypnotism;
Anticonvulsion
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the sedative and hypnotic effects of Ganoderma lucidum brewage(GLB).Methods The NIH mice were given with gavage of GLB 0.06,0.12,and 0.24g/kg per day respectively for 15 days.The spontaneous motion,the sleeping time induced by pentobarbital sodium in subthreshold dosage and threshold dosage,and the number of mice subjected to pentylenetetrazol-induced convulsion were observed.Results GLB can reduce the spontaneous motion,significantly longthen the mice sleeping time of pentobarbital sodium in threshold dosage and increase the number of sleeping mice under subthreshold dosage of pentobarbital sodium.GLB was synergic with pentobarbital sodium,and antagonized pentylenetetrazol-induced convulsion in a dose-dependent manner.Conclusion GLB possesses obvious sedative,hypnotic and anticonvulsive effects.
