CHANGES OF GABA AND GLUTAMATE IMMUNOREACTION IN BRAIN OF RATS WITH EPILEPSY INDUCED BY IL-? OR IL-6
- VernacularTitle:白细胞介素-1?或白细胞介素-6致痫大鼠脑内?-氨基丁酸和谷氨酸免疫反应性的变化
- Author:
Xiaoqin ZHU
;
Zhengli LI
- Publication Type:Journal Article
- Keywords:
Epilepsy;
IL-1?;
IL-6;
Glu;
GABA;
Immunoreaction;
Rat
- From:
Acta Anatomica Sinica
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The changes of Glutamic acid(Glu) and GABA immunoreaction in the cerebral cortex and hippocampus of rats with seizure induced by IL-1? and IL-6 were studied.To explore the mechanism of IL-1? and IL-6 in epilepsy. Methods Experimental rats were randomly divided into 3 groups:control group,IL-1? group,and IL-6 group.After intracerebroventricular injection of relevant reagents for 120?min,behaviour changes were observed,Glu and GABA were examined by means of immunohistochemistry in the cerebral cortex and hippocampus of rats. Results The behaviour observation indicated that no seizure happened in control group,seizure in middle degree was observed in IL-1? group and IL-6 group.Compared with in control group,the immunoreaction of Glu showed that the expression was significantly increased in IL-1? group and IL-6 bgroup,while GABA was obviously decreased after intracerebroventricular injection IL-1? or IL-6 at 120?min.Conclusion The machanism of that IL-1? or IL-6 particpated in promotion and abduction epilepsy may be through increasing Glu and decreasing GABA in the cerebral cortex and hippocampus.The nerve excitation is enhanced and then epilepsy occurred.
