Clinical significance of pre-operative combined detection of metastasis-relative genes in non-small cell lung cancer
- VernacularTitle:非小细胞肺癌术前转移相关基因联合检测的临床意义
- Author:
Bo LIU
;
Ying WANG
;
Jiaqi QU
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung Lymphatic metastasis Gene expression
- From:Chinese Journal of Thoracic and Cardiovascular Surgery
1995;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to investigate the clinical significance of pre-operative combined detection of metastasis-relative genes in non-small cell lung cancer. Methods Peripheral blood lymphocyte specimens from 46 patients before operation and fresh tissue specimens after operation were examined by RT-PCR analysis of CD44v6 and nm23H1 mRNA. The results were compared to the pathological diagnosis of lymph node metastases. ROC curve was used to determine the cut-off value of pre-operative metastases prediction. Results The relative amount of CD44v6 mRNA was higher (P
