Experimental study on inhibitory effect of glycyrrhizin on HSV-1 in vitro
- VernacularTitle:甘草甜素对HSV-1抑制作用的实验研究
- Author:
Gaonian ZHAO
- Publication Type:Journal Article
- Keywords:
Glycyrrhizin;
HSV- 1;
Plaque formation units
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the inhibitory effect of glycyrrhizin on HSV-1 in vitro,and to search a new drug against herpes simplex encephalitis.Methods:The Vero cells were cultured and divided into three groups:the group treated with glycyrrhizin after absorption of HSV-1 into the Vero cells,the group of pretreated cells and the group of pretreated HSV-1 with both glycyrrhizin before absorption of HSV-1 into the Vero cells.The plaque formation units were observed to evaluate the inhibitory effect of glycyrrhizin on HSV-1 and the stage when the virus replicating was inhibited.Results:Glycyrrhizin treatment after the absorption of virus into the cells obviously reduced the plaque formation units due to the virus infection and IC 50 was 0.56mM.Pretreated cells and pretreated HSV-1 with glycyrrhizin before absorption of HSV-1 into the cells did not reduce the plaque formation units.Conclusion:Glycyrrhizin can markedly inhibit the replication of HSV-1 in Vero cells.Glycyrrhizin can not inhibit the virus absorption and inactivate the virus.
