Mechanism of Xiao Chaihu Decoction in the Treatment of Endometriosis
- VernacularTitle:小柴胡汤冲剂治疗子宫内膜异位症的作用机制
- Author:
Hui ZHENG
;
Liandong ZUO
- Publication Type:Journal Article
- Keywords:
Xiao Chaihu decoction;
Endometriosis;
Rats;
Fas protein;
Caspa se- 3 protein
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of Xiao Chaihu decoction in t he treatment of endometriosis in rats.Methods The rat model of endometriosis w as established. Fas and Caspase- 3 protein expression in the eutopic endometriu m and eutopic endometrium were observed by immunohistochemical method.Results The protein expression of Fas and Caspase- 3 in ectopic endometrium of Xiao Cha ihu decoction group was higher than that in the eutopic endometrium, while the r esult in the control group was just the opposite. No significant difference was shown in Danazol group. Conclusion The therapeutic mechanism of Xiao Chaihu de coction for endometriosis may be related to the promotion the apoptosis of ectop ic endometrium tissue by increasing Fas protein expression.
