HISTOCHEMICAL OBSERVATIONS ON THE RENAL TUBULO-TOXICITY OF GOSSYPOL
- VernacularTitle:棉酚对肾小管毒性影响的组织化学观察
- Author:
Kai CHENG
;
Xiaomei CHEN
;
Shepu XUE
- Publication Type:Journal Article
- Keywords:
gossypol;
potassium loss;
tubulo-toxic agent
- From:
Acta Anatomica Sinica
1989;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Gossypol has been shown to cause a side effect hypokalemia. This study was designed to evalulated the possible role of gossypol in relation to renal potassium loss by using histochemical method for comparative analysis of gossypol and gentamicin, a well known tubulo-toxic agent, as positive control with respect to nephrotoxic demage in rats and guinea pigs. The results indicated that gossypol had obvious effect on reabsorption function by inducing transitional decrease of membrane enzymes activities of renal tubular cells but had no effect as comparable with gentamicin to cause structureal damage of tubular cells.
