Significance of ERK/MAPK signal transduction pathway in the targeting treatment of gastrointestinal cancer
- VernacularTitle:ERK/MAPK信号传导通路在胃肠道肿瘤治疗靶向中的意义
- Author:
Jianxiong HUANG
;
Pei WU
- Publication Type:Journal Article
- Keywords:
ERK/MAPK;
signal transduction;
gastroenteric tumor;
inhibitor;
therapy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular signal-regulated kinase/mitogen-activated protein kinase(ERK/MAPK) signaling pathway plays an important role in gastrointestinal tumorigenesis and development.ERK/MAPK signal transduction pathway has three important molecular targets: the small G protein Ras,Raf kinase and MEK1/2 and ERK1/2.At present,there are three kinds of approach which can inhibit ERK / MAPK signal transduction pathway:⑴ destroying the structure and(or) function of the target protein,⑵adopting the deficit strategy,⑶damaging the interaction between proteins.These approaches can provide new ideas for the treatment of gastrointestinal cancer.
