Effects of roxithromycin on NF-?B activity and bronchial hyperresponsiveness of asthma rats
- VernacularTitle:罗红霉素对哮喘大鼠NF-?B及气道炎症的影响
- Author:
Sunshun YAN
;
Yuanrong DAI
;
Liqin WU
;
Xiaodong XIA
- Publication Type:Journal Article
- Keywords:
asthma;
roxithromycin;
NF-?B;
bronchial hyperresponsiveness
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of roxithromycin on the NF-?B activity,the airway inflammation and bronchial hyperresponsiveness of asthma rats.METHODS: Thirty male adult Sprague-Dawley rats were randomly divided into the control group(Group C,n=10),asthma group(Group A,n=10) and roxithromycin group(Group R,n=10).The asthma model was induced by ovalbumin and Al(OH)3.The airway reactivity was detected and then rats in each group were sacrificed after 24 hours for the last provocation.The concentrations of IL-4,IL-5 and IFN-? in bronchoalveolar lavage fluid(BALF) were measured by ELISA,and the activity of NF-?B protein in bronchial epithelium was detected by immunohistochemistry.RESULTS: Compared with Group C,the airway reactivity in Group A was increased(P
