Effects of vitamin E on secretion of inflammatory mediators of human monocytes by advanced glycation end products
- VernacularTitle:维生素E对晚期糖基化终产物诱导的炎症介质的干预作用
- Author:
Yuan WU
;
Fang LIU
;
Qun CHEN
- Publication Type:Journal Article
- Keywords:
vitamin E;
advanced glycation end products;
inflammatory mediators;
end stage,renal disease
- From:Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of vitamin E(VitE) on TNF-?,IL-1? and nitric oxide(NO) secretion from human monocytes stimulated by advanced glycation end products.Methods Human peripheral blood monocytes(PBMCs) from 20 hemodialysis(HD) patients and 15 normal volunteers were isolated.These PBMCs were cultured in vitro with advanced glycation end products(AGE) and vitamin E.All of these PBMCs were divided into control group,AGE-inducing group,different doses VitE group and different culture VitE group.The levels of TNF-? and IL-1? in supernatants were detected by ELISA.The levels of NO were detected by biochemical method.Results The basal secretion of TNF-?,IL-1? in monocytes from HD patients was more than those from normal volunteers.AGE induced significantly more secretion of TNF-? and IL-1?(P
