Neuroprotective effects of honokiol on mouse model with Parkinson's disease
- VernacularTitle:和厚朴酚在帕金森病小鼠模型中的神经保护作用
- Author:
Ying XU
;
Suoqin TANG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
honokiol;
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP);
models,animal;
neuroprotective agents
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the neuroprotective effect of honokiol against Parkinson's disease(PD)in mouse model,and investigate the possible mechanism involved.Methods 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)was injected into abdominal cavity of mouse to establish the PD model.Sixty C57BL/6 male mice were randomly allocated into five groups:control group,MPTP model group,amantadine group(positive control,40mg/kg),honokiol group A(10mg/kg)and honokiol group B(30mg/kg).Spontaneous movement test was used to measure the activity frequency of each mouse in 5 minutes.The technique of high performance liquid chromatography-electrochemistry was utilized to detect the changes of dopamine(DA)contents in mouse striatum.Results a)Since the involuntary movement appeared,such as trunk trembling,piloerection,tail extending and movement reduction,the PD model was regarded as having been reproduced successfully.b)The spontaneous movement frequency in 5 minutes of the mice in MPTP model group(102?7)was lower than that in the control group(583?11,P
