The role of p38MAPK transduction system in chronic bronchitis
- VernacularTitle:丝裂原活化蛋白激酶亚族p38信号转导通路与慢性支气管炎的关系
- Author:
Xiaoming MENG
;
Yan HUANG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
mitogen activated protein kinase;
alveolar macrophage;
chronic bronchitis;
NF-?B
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Mitogen activated protein kinase(MAPK) is one of the four biggest signal transduction systems which contain four subtribes named p38,ERK5/BMK1,ERK and JNK/SAPKrespectively.Previous studies have shown that MAPK pathway is involved in growth,cell differentiation,perishing,the synchronization of cell function and so on.p38MAPK,one of the members of MAPK family,plays an important role in the activation of inflammation-related cells to release inflammation mediator,modulating enzyme production as well as transferring factors activity in the process of chronic bronchitis(CB).This review focuses on multiple roles of p38MAPK in the pathogenesis and progression of CB.
