EFFECT OF SOY ISOFLAVONES ON MENOPAUSAL SYMPTOMS IN EARLY POSTMENOPAUSAL CHINESE WOMEN
- VernacularTitle:大豆异黄酮对绝经早期妇女围绝经期症状的改善效应观察
- Author:
Yanbin YE
;
Zilian WANG
;
Yixiang SU
;
Yuming CHEN
;
Shuyu ZHUO
;
Shi FANG
- Publication Type:Journal Article
- Keywords:
soy isoflavones;
menopausal symptoms;
ovarian hormone;
gonadotropins
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of soy isoflavones(SI) on menopausal symptoms,and its mechanism.Methods Ninety early postmenopausal women were randomly assigned to three treatment groups with daily dosages of 0(placebo),84,126 mg/(kg bw?d) SI(n=30).Hot flash frequency and Kuppermann score and serum 17?-estrodiol(E2),follicle-stimulating hormone(FSH) and luteinizing hormone(LH) were assessed at baseline,12 w and 24 w posttreatment.Results The percent decreases of Kuppermann scores and hot flashes frequency of the two SI treatment groups were 57.8%?37.4%and 44.3%?19.1% in low dose group and(56.7?26.7)% and(48.5?27.2)% in high dose group respectively,significantly higher than those of the placebo group(34.6?46.2)% and(27.8?15.5) %.No significant difference was observed between the two SI groups.The contents of E2,FSH and LH among all groups were insignificantly different.Conclusion A daily dosage of 84 mg soy isoflavones or above could improve menopausal symptoms especially reducing hot flashes frequency and the mechanism seems not associatedwith serum E2,FSH,and LH.
