THE COMPARATIVE STUDY ON EFFECTS OF GREAN TEA AND BLACK TEA POLYPHENOLS ON GENES RELATED TO ADIPOCYTE DIFFERENTIATION IN RATS
- VernacularTitle:绿茶和红茶多酚对大鼠脂肪分化相关基因表达影响的比较研究
- Author:
Juan YI
;
Huijun DENG
;
Jin CAO
- Publication Type:Journal Article
- Keywords:
green tea polyphenols;
black tea polyphenols;
obesity;
adipocyte differentiation
- From:
Acta Nutrimenta Sinica
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the anti-obesity effect of green tea and black tea polyphenols and investigate their molecular mechanisms. Method:Rats were divided randomly into four groups:control group,high-fat group,high-fat diet with green tea polyphenols(GTP) supplement group,and high-fat diet with black tea polyphenols(BTP) supplement group. Body weight was determined every 2 w. After 3 months,the changes of epididymal fat tissues weight and serum lipids were observed. Expressions of those genes associated with adipocyte differentiation in epididymal fat tissues of rats were measured by real-time transcription-polymerase chain reaction,including pref-1,aP2,TNF-?,leptin,PPAR-?,C/EBP-? . Results:Both GTP and BTP prevented the increase of body weight and fat induced by high-fat diet and profoundly down-regulated those adipocyte-specific genes,including aP2,TNF-?and leptin. In addition,GTP also up-regulated the pre-adipocye marker — pref-1 and reduced the expression of transcription factor,peroxisome proliferators-activated receptor(PPAR-?) . Conclusion:Tea polyphenols could prevent obesity by reversing the adipocyte differentiation,and GTP possessed stronger inhibitory effect than BTP.
