Green tea catechins neuroprotection mediated by nAChR
- VernacularTitle:nAChR介导茶多酚EGCG的神经保护作用
- Author:
Jianying TIAN
;
Hao YANG
- Publication Type:Journal Article
- Keywords:
nAChR;
EGCG;
A?
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study whether or not the green tea catechins(EGCG)has physiological benefits and the underling protective mechanism.Methods The subunit protein levels of ?4、?7 of nAChR were detected by BCA protein assay,Dot Blot assay and MTT assay.Results The results showed that the green tea catechins can significantly reduce the subunit protein levels of nAChR and decrease the cell activity induced by A?1-40.Conclusions EGCG can provide neuroprotection in vitro by up-regulating nAChR sununit levels and inhibiting the neurotoxin of A?1-40.
