Protective effects of aFGF on gentamicin-induced injuries of rats'renal tubular epithelial cells in vitro
- VernacularTitle:酸性成纤维细胞生长因子对庆大霉素诱导的肾小管上皮细胞损伤的保护作用
- Author:
Juen HUANG
;
Huijie WANG
;
Huagang LIU
;
Haiyan LIU
;
Xiaokun LI
;
Jian XIAO
- Publication Type:Journal Article
- Keywords:
aFGF;
gentamicin;
renal tubular epithelial cell;
cell culture
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study protective effects of aFGF on rats' renal tubular epithelial cells injured by gentamicin in vitro.Methods After renal cortice were grounded,filtered and digested with 0.25%trypsin,renal tubular epithelial cells were cultured.The injury models of epithelial cells of renal tubules were established by gentamicin and then the protective roles of aFGF in injured renal tubular epithelial cells were observed.Results ① By observing the morphology of the epithelial cells and comparing GM group with control group,CAT、SOD、Na~+,K~+-ATP enzyme activities decreased,while NAG activity and MDA level increased(P
