The growth hormone-insulin-like growth factor axis and colorectal cancer
- VernacularTitle:生长激素-胰岛素样生长因子轴与结直肠癌
- Author:
Xiaoyu WU
;
Zhe XU
- Publication Type:Journal Article
- Keywords:
Growth hormone;
Insulin-like growth factor;
Colorectal cancer
- From:
Parenteral & Enteral Nutrition
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The growth hormone(GH)-insulin-like growth factor(IGF)-I axis is an important modulator of growth and development.In addition to the classical role as endocrine hormones,the components also regulate a wide range of biological functions through paracrine and autocrine mechanisms.Their potent mitogenic and anti-apoptotic effects play a critical role in the regulation of rapidly renewing epithelial cell populations such as those found in the colon.Recent epidemiological evidence from acromegaly patients suggests an association between inappropriate regulation of the GH-IGF-I axis and the development of colorectal cancer.However,the molecular mechanisms and signalling pathways responsible are only beginning to be unravelled,as are the relative contributions of the endocrine and autocrine or paracrine effects.
