Study on in situ intestinal absorption kinetics of icariin in rats
- VernacularTitle:淫羊藿苷大鼠在体肠吸收动力学的研究
- Author:
Yanhong ZHAO
;
Xiaobin JIA
;
Yan CHEN
;
Hu MING
- Publication Type:Journal Article
- Keywords:
Icariin;
Absorption kinetics;
In situ intestine perfusion model;
Experimental study
- From:China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the absorption kinetics characteristics of icariin for various intestinal segments.Methods: To establish the situ intestinal perfusion model and to study the absorption of icariin for various intestinal segments.Results: Icariin was metabolized quickly in the four intestinal segments.The permeability coefficient(P*eff) were(4.27?0.28),(5.25?0.17),(1.99?0.09),(0.80?0.03) at duodenum,jejunum,ileum,colon,respectively.Icariside can be detected in the four intestine segments in rats by HPLC.Conclusion: Icariin is metabolized into icariside,and then icariside can be absorbed.
