Effects of probucol on ox-LDL induced apoptosis and CD36,Caveolin-1 expression in THP-1 macrophages
- VernacularTitle:普罗布考在抗ox-LDL诱导THP-1巨噬细胞凋亡中对CD36、Caveolin-1表达的影响
- Author:
Bo SU
;
Hui HE
;
Qifu LUO
;
Bingyang ZHU
;
Duanfang LIAO
- Publication Type:Journal Article
- Keywords:
probucol;
ox-LDL;
macrophages;
apoptosis;
CD36;
Caveolin-1
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of probucol on THP-1 macrophage apoptosis and CD36、Caveolin-1 expression induced by ox-LDL.Methods Apoptosis of THP-1 macrophages was determined by flow cytometry analysis.RT-PCR and immunofluorescence were used to detect CD36,Caveolin-1 mRNA level and protein expression respectively.Results Probucol had no effect on mRNA level of CD36,Caveolin-1 in THP-1 macrophages,but it attenuated Caveolin-1 protein expression.Conclusions Probucol can inhibit apoptosis induced by ox-LDL in THP-1 macrophages by down-regulating Caveolin-1 protein expression.
