Efficacy of adefovir dipivoxil in treating patients with hepatitis B resistant to lamivudine
- VernacularTitle:阿德福韦酯治疗拉米夫定耐药慢性乙型肝炎的疗效观察
- Author:
Wenli LI
;
Shipin WU
- Publication Type:Journal Article
- Keywords:
chronic hepatitis B;
lamivudine resistance;
adefovir dipivoxil
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the efficacy and safety of adefovir dipivoxil in treating patients with hepatitis B resistant to lamivudine. METHODS: 68 patients with hepatitis B resistant to lamivudine were administered 10 mg adefovir dipivoxil orally daily for over 1 years.The serum HBV-DNA levels were measured by quantitative PCR and liver function test,HBeAg/anti-HBe and safety assessments were also performed at 0,12,24,52 weeks after treatment. RESULTS: After 12,24,52 weeks of treatment, the mean HBV-DNA levels were reduced by 1.6 lg copies/mL (t=10.10,P
