Effect of irbesartan on the change of matrix metalloproteinase-13 in right atrial myocardium after acute atrial fibrillation in rabbits
- VernacularTitle:厄贝沙坦对兔急性心房颤动后心房肌基质金属蛋白酶-13表达影响的实验研究
- Author:
Wei PAN
;
Xiufen QU
;
Yonglin HUANG
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
Matrixmetalloproteinases;
Tissue inhibitors of metalloproteinase;
Angiotensin Ⅱ;
Irbesartan
- From:
Chinese Journal of Practical Internal Medicine
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of matrix metalloproteinase-13(MMP-13)in right atrial myocardium after acute atrial fibrillation in rabbits and evaluate the effect of irbesartan on the atrial remodeling following atrial fibrillation.Methods From Jan.2005 to Jun.2005,60 rabbits were randomly divided into groups of no drug(n=30)and receiing drug(n=30),the receiving drug group taking irbesartan for 3 weeks(30mg/kg).Each group was randomly divided into groups of control(n=10),atrial fibrillation control(n=10),8 h after atrial fibrillation(n=10).The amount of MMP-13、tissue inhibitors of metalloproteinase-3(TIMP-3)、angiotension receptor 1(AT1)and angiotension receptor 2(AT2)in right atrial myocardium measured by immunohistochemical stain.The amount of angiotension Ⅱ(AngⅡ)in right atrial myocardium was measured by radioimmunoassays.Results The amount of MMP-13 in ND3 was higher than in ND1(P
