Endoscopic variceal ligation vs ?-blockers for prevention of first variceal bleeding in cirrhosis:a Meta-analysis
- VernacularTitle:食管静脉曲张套扎术和?-受体阻滞剂预防肝硬化初次出血的Meta分析
- Author:
Wandong HONG
;
Qihuai ZHU
;
Qingke HUANG
- Publication Type:Journal Article
- Keywords:
Cirrhosis;
Variceal bleeding;
Endoscopic variceal ligation;
?-blockers;
Meta-analysis
- From:
Chinese Journal of Practical Internal Medicine
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of endoscopic variceal ligation(EVL)with ?-blockers(BB)in prophylaxis on the rate of first esophageal variceal bleeding in patients with cirrhosis.Methods We searched Cochrane Central Register of Controlled Trials(4th Quarter 2006)、MEDLINE(1966—2006-10)、EMBASE(1985—2006-10),CJFD(1994—2006)and handsearched the related journals to identify Randomized Controlled Trials(RCT)of endoscopic variceal ligation(EVL)and ?-blockers for prevention of first variceal bleeding in cirrhosis.Meta-analysis was conducted using the method recommended by The Cochrane Collaboration.Results Eight trials were included.Summary RR of meta-analysis showed a significant reduction in EVL group in rate of first variceal hemorrhage(RR=0.63,95%CI:0.46,0.85;P=0.0003;RRR=0.37,NNT=12)and severe adverse events(RR=0.23,95%CI:0.12,0.43;P
