THE INHIBITORY EFFECT OF GRAPE PROANTHOCYANIDINS ON P38MAPK PATHWAY IN BREAST CANCER CELLS
- VernacularTitle:葡多酚对乳腺癌细胞P38MAPK信号传导通路的影响
- Author:
Rong ZHAO
;
Jinyi ZHONG
- Publication Type:Journal Article
- Keywords:
grape proanthocyanidins;
breast cancer;
P38MAPK;
matrix metalloproteinase-2;
signal pathway
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the inhibitory effect of grape proanthocyanidins (GPC) on P38 mitogen-activated protein kinase(P38MAPK)pathway in mice with breast cancer . Methods: BALB/C mice inoculated with EMT-6 breast cancer cells were given 10, 100 and 200 mg/kg bw GPC po daily for 2 w. The expression levels of phosphorylated P38MAPK and matrix metalloproteinase-2(MMP-2)protein were detected by Western blot. Results: The levels of phosphorylation P38MAPK in tumor control group and 200 mg/kg GPC group were 1.16?0.18 和 0.58?0.12 respectively,and the levels of MMP-2 protein were 0.98 ?0.04 和 0.69?0.04 respectively. The differences between the two groups were significant (P
