Advanced glycation end products cross-links and diabetic-induced endothelium dysfunction
- VernacularTitle:晚期糖基化终产物靶向治疗药物与糖尿病血管内皮功能紊乱
- Author:
Bing ZHANG
;
Gang CHENG
;
Lili WANG
;
Song LI
- Publication Type:Journal Article
- Keywords:
advanced glycation end products;
endothelial cell;
diabetes mellitus
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic vascular complications are the key cause of the poor life quality and high mortality in diabetic patient. Advanced glycation end products (AGEs) and its cross-links play important roles in the diabetic vascular complications. Endothelial cells damage induced by AGEs may account for the initial agent for diabetic vascular complications. Recent studies have shown that AGEs inhibitors and breakers can prevent and reverse these complications. This article reviewed the research progress of AGEs and endothelium dysfunction. The potential therapeutic method was also stated.
