Clinical Characteristics of Transplant-associated Encephalopathy in Children.
10.3346/jkms.2017.32.3.457
- Author:
Yun Jeong LEE
1
;
Mi Sun YUM
;
Eun Hee KIM
;
Min Jee KIM
;
Kyung Mo KIM
;
Ho Joon IM
;
Young Hwue KIM
;
Young Seo PARK
;
Tae Sung KO
Author Information
1. Department of Pediatrics, Kyungpook National University Hospital, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Encephalopathy;
Transplantation;
Liver;
Kidney;
Heart;
Hematopoietic Stem Cells
- MeSH:
Brain Diseases*;
Brain Diseases, Metabolic;
Child*;
Chungcheongnam-do;
Heart;
Heart Transplantation;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Hypertensive Encephalopathy;
Incidence;
Kidney;
Kidney Transplantation;
Liver;
Liver Transplantation;
Medical Records;
Mortality;
Quality of Life;
Retrospective Studies;
Transplant Recipients;
Transplantation;
Transplants
- From:Journal of Korean Medical Science
2017;32(3):457-464
- CountryRepublic of Korea
- Language:English
-
Abstract:
We aimed to analyze characteristics of encephalopathy after both hematopoietic stem cell and solid organ pediatric transplantation. We retrospectively reviewed medical records of 662 pediatric transplant recipients (201 with liver transplantation [LT], 55 with heart transplantation [HT], and 67 with kidney transplantation [KT], 339 with allogeneic hematopoietic stem cell transplantation [HSCT]) who received their graft organs at Asan Medical Center between January 2000 and July 2014. Of the 662 patients, 50 (7.6%) experienced encephalopathy after transplantation. The incidence of encephalopathy was significantly different according to the type of organ transplant: LT, 16/201 (8.0%), HT, 13/55 (23.6%), KT, 5/67 (7.5%), and HSCT, 16/339 (4.7%) (P < 0.001). Drug-induced encephalopathy (n = 14) was the most common encephalopathy for all transplant types, but particularly after HSCT. Hypertensive encephalopathy was the most common after KT and HT, whereas metabolic encephalopathy was the most common after LT. The median time to encephalopathy onset also differed according to the transplant type: 5 days after KT (range 0–491 days), 10 days after HT (1–296 days), 49.5 days after HSCT (9–1,405 days), and 39 days after LT (1–1,092 days) (P = 0.018). The mortality rate among patients with encephalopathy was 42.0% (n = 21/50). Only 5 patients died of neurologic complications. Transplant-associated encephalopathy presented different characteristics according to the type of transplant. Specialized diagnostic approach for neurologic complications specific to the type of transplant may improve survival and quality of life in children after transplantation.
