Calcium homeostasis deregulation in glutamate-induced excitotoxicity and its role in neurodegenerative diseases
- VernacularTitle:兴奋性神经毒性中的钙稳态失调及其在退行性病变中的作用
- Author:
Zhenyu REN
;
Xiaoqian YU
;
Shuangqing PENG
- Publication Type:Journal Article
- Keywords:
glutamate;
excitotoxicity;
calcium;
mitochondrial;
neurodegeneration
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Excitotoxicity refers to a process of neuronal death caused by excessive or prolonged activation of receptors for the excitatory amino acids, which is related to the overload of intracellular calcium ([Ca2+]i) and mitochondrial depolarization. The well accepted hypothesis that Ca2+ plays a central role in neurotoxicity, and it mediated excitotoxicity is deeply involved in both acute and chronic neurodegeneration suggests that inhibitors of Ca2+ transduction, such as NMDA antagonists, might block the pathological process at an early stage and provide more effective protections.
