Protective effect of modified acidic fibroblast growth factor on renal ischemia/reperfusion injury of rats
- VernacularTitle:改构型酸性成纤维细胞生长因子对大鼠肾缺血/再灌注损伤的保护作用
- Author:
Wenjuan HU
;
Juen HUANG
;
Xiaokun LI
;
Jian XIAO
- Publication Type:Journal Article
- Keywords:
modified acidic fibroblast growth factor;
renal ischemia/reperfusion injury;
acute renal failure;
rat
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the protective effect of modified acidic fibroblast growth factor (MaFGF) on renal ischemia/reperfusion injury of rats. Methods 32 Wistar rats were divided randomly into four groups;false operative control group, model control group, 8 ?g?kg-1 of MaFGF and 16 ?g?kg-1 of MaFGF groups with 8 animals in each group. Renal pathological changes were observed by light and electron microscope. Results As shown in pathology, compared with model control group, MaFGF group could significantly reduce edema, number of leukocytes appearing in the interstitium ,distention and destroy of renal tissues. Under EM, the ultrostructure(including microvilli, mitochondria and lysosomes etc.) of the tubular epithelial cells of MaFGF groups appeared lighter in injuries or even near normal. Conclusion MaFGF has a role in attenuation of renal damage or failure after ischemia-reperfusion injury of the kidney.
