Inhibition of glycine-activated current by total flavones of epimedium in rat spinal dorsal horn neurons
- VernacularTitle:淫羊藿总黄酮抑制大鼠脊髓背角神经元甘氨酸激活的全细胞电流
- Author:
Xinping CHENG
;
Feng ZHU
;
Keqing ZHOU
- Publication Type:Journal Article
- Keywords:
total flavones of epimedium (TFE);
glycine receptor;
whole-cell patch-clamp technique;
spinal dorsal horn neurons
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate total flavones of epimedium (TFE) modulation of glycine-activated current (IGly) in acutely dissociated rat spinal dorsal horn neurons. Method Whole-cell patch-clamp technique was used. Result TFE inhibited IGly reversibly in a concentration-dependent manner. It shifted the concentration-response relationship to the right without altering the maximum response and Hill coefficient of the IGly. TFE did not change the ion selectivity of glycine receptor either. Conclusion These results indicate that TFE directly inhibited the glycine receptor response by decreasing the affinity of glycine to its receptor.
