Loureirin B inhibits capsaicin-induced currents in rat dorsal root ganglion neurons
- VernacularTitle:龙血素B抑制大鼠背根神经节细胞辣椒素诱发的电流反应
- Author:
Can WANG
;
Su CHEN
;
Xiangming LIU
- Publication Type:Journal Article
- Keywords:
loureirin B;
capsaicin;
whole-cell patch-clamp technique;
dorsal root ganglion neuron
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate effects of loureirin B on capsaicin-evoked currents in rat dorsal root ganglion (DRG) neurons. Methods In acutely isolated rat DRG neurons, effects of loureirin B on capsaicin-evoked currents were observed using whole-cell patch-clamp technique. Results ① The holding potential was maintained at -60 mV and VR1 antagonist capsazepine inhibited capsaicin-evoked currents completely; ② Loureirin B concentration-dependently inhibited capsaicin-evoked currents. Loureirin B at the concentrations of 2.0, 4.0, 8.0 and 16.0 ?mol?L-1 reduced capsaicin-evoked currents by 15.36%?2.12%、36.41%?2.43%、76.26%?2.16% and 96.69%?3.21% (n=10, P
