Neuroprotective effect of acteoside against MPTP-induced mouse model of Parkinsons disease
- VernacularTitle:类叶升麻苷对MPTP所致帕金森病小鼠模型的神经保护作用
- Author:
Lei ZHAO
;
Xiaopin PU
- Publication Type:Journal Article
- Keywords:
acteoside;
MPTP;
PD model;
tyroxine hydroxylase;
?-synuclein;
neuroprotection
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the neuroprotective effect of Acteoside against MPTP-induced mouse model of Parkinsons disease (PD) and its mechanism. Methods The behavioral testing of C57 mice was assessed using spontaneous movement and rotarod test. DA levels in striatum were measured using HPLC-EC. Dopaminergic neurons in the substantia nigra were observed by immunohistochemical staining with an anti-Tyroxine hydroxylase (TH) antibody. Moreover, the mechanism of the neuroprotective effect of acteoside was investigated using Western blot analysis with an anti-?-synuclein antibody in the substantia nigra and striatum. Results ① Compared with control, MPTP lesion significantly reduced the number of spontaneous movement and latent period of mice on the rotating rod (both P
