Influence of gene polymorphism of aldosterone synthese gene CYP11B2(-344T/C)on antihypertensive response to Valsartan in Han nationality essential hypertension patients in Beijing.
- VernacularTitle:醛固酮合成酶基因CYP11B2(-344T/C)多态性对北京汉族人群高血压患者缬沙坦降压疗效的影响
- Author:
Ji XU
;
Qi HUA
;
Dongbao LI
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Aldosterone synthese;
Gene polymorphism
- From:
Chinese Journal of Practical Internal Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between gene polymorphism of aldosterone synthese gene CYP11B2(-344T/C)and essential hypertension and to observe the antihypertensive response to Valsartan in Han nationality in Beijing.Methods Polymerase chain reaction was used to detect the polymorphism of aldosterone synthese gene CYP11B2(-344T/C)in 345 hypertensive patients(EH)and 157 normotensive controls(NE)from Aug.1999 to Oct.2003.Clinical blood pressure and biochemical index were also detected.Blood pressure was repeated in 98 patients with Valsartan treatment for 4 weeks.Results The frequencies of CC+CT genotype of aldosterone synthese gene CYP11B2(-344T/C)polymorphism among EH was significantly higher than that among NE(P
