Neuroprotective effects of stearic acid in primarily cultured hippocampal neurons insulted by excitotoxicity
- VernacularTitle:硬脂酸对兴奋性损伤的原代培养海马细胞的神经保护作用
- Author:
Guangmei LI
;
Zejian WANG
;
Xueqin CHEN
;
Guoyuan HU
;
Ming YIN
- Publication Type:Journal Article
- Keywords:
stearic acid;
excitotoxicity;
PPAR?
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate neuroprotective effects of stearic acid on primarily cultured hippocampal neurons and to study the mechanism of neuroprotection afforded by stearic acid.Methods Primarily cultured hippocampal neurons were insulted by OGD(oxygen-glucose deprivation),H_2O_2,glutamate and NaN_3;MTT assay was utilized to evaluate cell viability;Inhibitors of PPAR?and PI-3K signal pathway were used to study mechanisms of neuroprotection of stearic acid.Results Compared with control neurons,A_(570) in MTT assay were increased significantly by stearic acid in hippocampal neurons insulted by OGD(oxygen-glucose deprivation),H_2O_2 and glutamate(P
