Progress in Research on Neuroprotective Effects of Statins
- VernacularTitle:他汀类药物神经保护作用的研究进展
- Author:
Jun LI
;
Jiami WU
;
Zhaohu CHU
;
Hengsheng SHEN
- Publication Type:Journal Article
- Keywords:
statins;
neuroprotection;
cerebral ischemia;
dementia
- From:
International Journal of Cerebrovascular Diseases
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Statins can substantially lower the incidence of cerebral ischemia and attenuate cerebral ischemic injury. Statins may exert their protective effects via different mechanisms, including stabilizing atherosclerotic plaques, improving endothelial function, reducing inflammatory reaction and reperfusion injury. Moreover, they may also reduce the occurrence of dementia by preventing ?-amyloid from formation and reducing secretion of apolipoprotein E.
