The Damage Mechanisms of Iron Ion in Intracerebral Hemorrhage and the Neuroprotective Effects of Iron Chelator
- VernacularTitle:铁离子在脑出血中的损伤机制及铁螯合剂的神经保护作用
- Author:
Yudan FANG
;
Shuijiang SONG
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
iron ion;
iron-chelator;
oxidative damage
- From:
International Journal of Cerebrovascular Diseases
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
A series of pathophysiologic changes in brain tissues will occur after intracerebral hemorrhage, including the enlargement of hematoma, metabolism abnormality in perihematoma tissues, and formation of cerebral edema. Recent researches have demonstrated that iron ions play an important role in the secondary brain injury after intracerebral hemorrhage. Iron chelator can block iron-induced injury process by specifically binding iron ions. This article reviews the changes of iron metabolism, iron-related mechanisms of brain injury, and the neuroprotective effect of iron chelator.
