Characteristics of obesity and role of ERK1/2 and p38MAPK in produetion of adipose tissue in rat with metabolic syndrome
- VernacularTitle:代谢综合征大鼠肥胖特征及ERK1/2和p38MAPK的作用研究
- Author:
Yaping ZHANG
;
Zhiming ZHU
;
Zhencheng YAN
- Publication Type:Journal Article
- Keywords:
metabolic syndrome;
obesity;
mitogen-activated protein kinases;
p38 MAP kinase
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the characteristics of obesity in rats with metabolic syndrome (MS) and to study the role of ERK1/2 and p38MAPK in the production of adipose tissues. Methods The metabolic parameters, weight of adipose tissue, waist circumference (WC), Lee's index, distribution area of adipocytes and the number of big adipocytes in the rats were measured. Adipose tissues and liver were histopathologically observed. ERK1/2 and p38MAPK of adipose tissue were determined using Western blot. Results (1) The blood pressure, fasting insulin level, LDL-C, TG and FFA in rats with MS were markedly higher than that in control rats (P
