Effects of budesonide on expression of basic fibroblast growth factor and mRNA in asthmatic rats
- VernacularTitle:布地奈德对哮喘大鼠碱性成纤维细胞生长因子蛋白和mRNA表达的影响
- Author:
Hui YE
- Publication Type:Journal Article
- Keywords:
asthma;
basic fibroblast growth factor;
budesonide;
rat
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effects of budesonide on expression of basic fibroblast growth factor and mRNA in asthmatic rats.METHODS: Thirty six male Sprague-Dawley rats were randomly divided into three equal groups,including asthma group,control group and budesonide treatment group.In this experiment,the rat model of asthma was established by the ovalbumin challenge methods.The concentration of basic fibroblast growth factor in bronchoalveolar lavage fluid(BALF)was measured by ELISA,the expression of the protein of basic fibroblast growth factor and mRNA were detected with immunohistochemistry methods and in situ hybridization methods.RESULTS: The concentration of basic fibroblast growth factor in bronchoalveolar lavage fluid,the protein and mRNA expression of basic fibroblast growth factor in lung tissue were significantly higher in the asthma group than those of control group(P
