Anti-aging effects of ginsenosides,tanshinone and chuanxionyzine on mice skin: a comparison study
- VernacularTitle:人参皂苷、丹参酮和川芎嗪抗小鼠皮肤衰老作用研究
- Author:
Hongli WANG
- Publication Type:Journal Article
- Keywords:
skin aging;
ginsenosides;
tanshinone;
chuanxionyzine
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the anti-aging effects of ginsenosides,tanshinone and chuanxionyzine on the skin of D-galactose-induced mice aging model.Methods: One hundred female mice were randomly divided into 5 groups(n=20).Mice in normal control group received subcutaneous injection of normal saline and mice in other 4 groups received cervicodorsal injection of D-galactose(1 000 mg?kg~(-1)?d~(-1)) for 42 d to establish subacute aging model.The experimental groups included aging model group(without further treatment),tanshinone-treated(1 500 mg?kg~(-1)?d~(-1)) group,chuanxionyzine-treated(150 mg?kg~(-1)?d~(-1)) group,and ginsenosides-treated(100 mg?kg~(-1)?d~(-1)) group.Forty-two days later,the dorsal skin samples were collected to determine SOD,CAT activities and MDA,hydroxyproline contents.Results: In tanshinone-and ginsenosides-treated groups,SOD activities increased from(131.2?21.5) U/ml to(203.1?11.2) U/ml and(196.8?27.5) U/ml,respectively;the contents of hydroxyprolin increased from(0.57?0.13) mg/g to(0.71?0.11) mg/g and(0.76?0.12) mg/g,respectively;and the contents of MDA decreased from(9.39?1.5) nmol/g to(6.4?1.3) nmol/g and(7.16?2.3) nmol/g,respectively(all P
