The Neuroprotective Effect of Erythropoietin on Cerebral Ischemic Injury
- VernacularTitle:红细胞生成素对脑缺血损伤的保护作用
- Author:
Zhongling SUN
;
Renliang ZHAO
- Publication Type:Journal Article
- Keywords:
erythropoietin;
cerebral ischemia;
neuroprotection
- From:
International Journal of Cerebrovascular Diseases
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Studies have shown that erythropoietin (EPO) may have neuroprotective effect on cerebral ischemia, and exogenous EPO may also exert neuroprotective effect on cerebral ischemic injury through blood-brain barrier. Its mechanisms may include the upregulation of the expressions of apoptosis inhibiting genes bcl-2 and bcl-xl, the expression of key proteases during the process of inhibiting apoptosis, inhibiting nitric oxide oversynthesis, protecting against glutamate-induced excitotoxicity, etc.
