Study about pharmacodynamics of radix notoginseng flavones on viral myocarditic models
- VernacularTitle:三七总黄酮对病毒性心肌炎模型治疗作用的药效学研究
- Author:
Fei SUN
;
Tonghui YI
;
Chongyang LIANG
;
Shuqin ZHANG
;
Zhiyi LIU
- Publication Type:Journal Article
- Keywords:
radix notoginseng flavones;
viral myocarditis;
COXB_3 virus
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the antiviral function of Radix Notoginseng flavone on a virus infection model caused by COXB_3 virus in vitro and in vivo. Methods To establish an experimental in vitro model of viral myocarditics based on primary culture of myocardial cells of newborn Wistar rats and a Balb/c mouse model of viral myocarditics through intraperitoneal injection. Results In vitro Radix Notoginseng flavone obviously inhibited pathologic change of cultured cardiac cells; it reduced release of enzymes from myocardial cells, and increased the level of interferon in mouse spleen, and inhibited inflammatory cells infiltration among cardiac cells in Balb/c mice infected by COXB_3 virus; survival rate of mice in treated groups increased. Conclusion Radix Notoginseng flavonoe has therapeutic efficacy on viral myocarditis caused by COXB_3 virus.
