The protective effect of extract of Picrhoriza scrophulariflora on renal ischemia/reperfusion injury
- VernacularTitle:胡黄连提取物在缺血再灌注肾损伤中的防治作用
- Author:
Yonghong YANG
;
Jianhua LI
;
Shangxi LIU
- Publication Type:Journal Article
- Keywords:
extracts of Picrorhiza scrophlariiflora Pennell;
reperfusion injury;
kidney
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of extract of Picrhoriza scrophulariflora on renal ischemia/reperfusion injury(I/R). Methods Male SD rats were randomly divided into sham-operated group (n=5), I/R group(n=8), I/R+ extracts of Picrhoriza scrophulariflora groups (each group had 8 rats). Acute renal ischemia/reperfusion injury in rats was reproduced by removing the right kidney and clamping the left renal artery with a non-traumatic vascular clamp for 60min followed by reperfusion for 72h. Serum creatinine, urine creatinine and renal pathological changes, were compared between I/R and I/R+ extracts of Picrhoriza scrophulariflora groups, malondialdehyde (MDA) and glutathione peroxidase (GSHPx). Results CCr levels were significant decreased after renal I/R injury. Kidneys of animal with I/R injury displayed significant pathological changes. 72h after ischemia, Ccr and serum GSHPx of animals of the I/R+ extracts of Picrhoriza scrophulariflora group were significantly higher than those of I/R group(P
