Neuroprotection of estrogen against injury induced by ?-amyloid protein (25-35) in rat cortical neurons
- VernacularTitle:雌激素对培养大鼠皮质神经元细胞?淀粉样蛋白(25-35)损伤的保护作用
- Author:
Lin ZHOU
;
Mulan REN
- Publication Type:Journal Article
- Keywords:
estrogen;
?-amyloid protein;
neuronal culture;
rats;
Alzheimer's disease
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of estrogen on injury induced by ?-amyloid protein (A?) in primary cultures of rat cortical neurons. METHODS: The effect of 17?-E_2 on A?(25-35)-induced cell death in primary rat cortical neurons was observed by phase contrast light microscopy, Giemsa staining and determination of lactate dehydrohenase (LDH) release rate. RESULTS: A?(25-35) induced cell death in rat primary cortical neurons. Forty eight hours pretreatment with 17?-E_2 protected rat primary cortical neurons from A?(25-35)-induced injury. CONCLUSION: A? evokes toxicity in rat primary cortical neurons. Estrogen can protect the rat primary cortical neurons against injury induced by A? (25-35).
