Impact of CYP3A4 and P-glycoprotein on drug disposition in intestine
- VernacularTitle:CYP3A4和P糖蛋白与药物的肠道处置
- Author:
Huawen XIN
- Publication Type:Journal Article
- Keywords:
CYP3A4;
P-glycoprotein;
drug metabolism;
intestine;
liver;
first-pass metabolism;
bioavailability;
drug interaction
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal CYP3A4-mediated biotransformation and active efflux of absorbed drug by P-glycoprotein are major determinants of bioavailability of orally administered drugs. The expression of CYP3A4 and P-glycoprotein in the intestine is not co-ordinately regulated. However, synergistic actions of CYP3A4 and P-glycoprotein in intestinal drug disposition have been confirmed by in vitro and animal studies. Further understanding of this interaction would be potentially useful to improve oral bioavailability of CYP3A4/P-glycoprotein substrates.
