Inhibition effects of methylprednisolone on over-expression of transforming growth factor-?_1(TGF-?_1) in kidneys of BXSB mice
- VernacularTitle:BXSB狼疮小鼠肾组织TGF-?_1异常表达及甲泼尼龙干预作用
- Author:
Meimei WANG
;
Xiaoxia ZHU
;
Rurong SUN
;
Leiting XU
- Publication Type:Journal Article
- Keywords:
methylprednisolone;
lupus nephritis;
kidney;
transforming growth factor-?_1;
mouse
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationship between TGF-?_1 over-expression and lupus nephritis(LN) in BXSB mice and whether MPS ameliorates LN by inhibiting the over-expression of TGF-?_1. METHODS: BXSB mice (experiment group, n=6) were treated (i.p.) with MPS (25 (mg?kg~(-1)?d~(-1))) dissolved in N.S for 3 weeks. The other age and sex-matched BXSB mice (n=6) and BALB/c mice (n=6) received N.S. alone. Proteinuria production was evaluated once a week. The expression of TGF-?_1 in the kidney was investigated by means of immunohistochemistry and RT-PCR. RESULTS: MPS significantly reduced proteinuria of BXSB mice (P
