Advances in the study of neuroprotective mechanisms of ganglioside GM1
- VernacularTitle:神经节苷脂GM1神经保护机制的研究进展
- Author:
Qing ZHANG
;
Pingping ZUO
- Publication Type:Journal Article
- Keywords:
GM1;
neuroprotective mechanisms
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
The monosialic acid ganglioside GM1 is rich in brain, which participates in the development process of the nerve system and plays wide neuroprotective roles. This article reviews recent reports about six neuroprotective mechanisms including: activating tyrosine kinase receptor——Trk receptor, modulating Ca 2+ homeostasis in cells, reducing the deposition of A? and its toxic roles in brain, inhibiting the production of reactive oxygen species, enhancing the activity of Na+,K+-ATPase.
